Experimental determination of the growth rate of Richtmyer-Meshkov induced turbulent mixing after reshock

The time evolution of the width of the turbulent mixing zone arising from the late development of Richtmyer-Meshkov instability is investigated in this work. This is achieved by means of the analysis of time-resolved Schlieren images obtained with a given set of shock-tube experiments. The post-reshock growth rate of the mixing zone width is found to be nearly insensitive to the development state of the mixing at the time of reshock

Study of the turbulent mixing zone induced by the Richtmyer-Meshkov instability using Laser Doppler Velocimetry and Schlieren visualizations

An experimental study of the compressible mixing generated by the Richtmyer-Meshkov instability (RMI) is carried out in a vertical shock tube by means of two-components Laser Doppler Velocimetry (2C-LDV) measurements and Time-resolved Schlieren visualizations. An attempt is made to quantify the RMI-induced air/sulphurhexafluoride (SF6) mixing by measuring turbulence levels inside the mixing zone at a given stage of its development and by extracting the growth rate of the mixing zone from the Schlieren images

LDV measurements in turbulent gaseous mixing induced by the Richtmyer-Meshkov instability: statistical convergence issues and turbulence quantification

A statistical characterization of the turbulent flow produced in a vertical shock tube dedicated to the study of the Richtmyer-Meshkov instability (RMI) is carried out using Laser Doppler Velocimetry (LDV), time-resolved Schlieren images and pressure histories. The time evolution of the phase-averaged velocity field and the fluctuating velocity levels produced behind the shock wave are first investigated for different configurations of a pure air, homogeneous medium. This allows us to determine the background turbulence of the experimental apparatus. Second, the RMI-induced turbulent Air/SF6 mixing zone (TMZ) is studied both in its early stage of development and after its interaction with a reflected shock wave (reshock phenomenon). Here the gaseous interface is initially produced by a thin nitrocellulosic membrane trapped between two grids. One of the most consistent issue regarding such a process is the generation of a large number of fragments when the incident shock wave crosses the interface. These fragments are likely to corrupt the optical measurements and to interact with the flow. This work seeks to clarify the influence of these fragments on the statistical determination of the velocity field. In particular it is shown that statistical convergence cannot be achieved when the fragments are crossing the LDV measurement volume, even if a significant number of identical experiments are superimposed. Some specific locations for the LDV measurements are however identified to be more favourable than others in the Air/SF6 mixing configuration. This finally allows us to quantify the surplus of turbulence induced by the reshock phenomenon

Experimental and numerical investigation of the growth of an air/SF6 turbulent mixing zone in a shock tube

Shock-induced mixing experiments have been conducted in a vertical shock tube of 130mm square cross section located at ISAE. A shock wave traveling at Mach 1.2 in air hits a geometrically disturbed interface separating air and SF6, a gas five times heavier than air, filling a chamber of length L up to the end of the shock tube. Both gases are initially separated by a 0.5 lm thick nitrocellulose membrane maintained parallel to the shock front by two wire grids: an upper one with mesh spacing equal to either ms=1.8mm or 12.1 mm, and a lower one with a mesh spacing equal to ml=1 mm. Weak dependence of the mixing zone growth after reshock (interaction of the mixing zone with the shock wave reflected from the top end of the test chamber) with respect to L and ms is observed despite a clear imprint of the mesh spacing ms in the schlieren images. Numerical simulations representative of these configurations are conducted: the simulations successfully replicate the experimentally observed weak dependence on L, but are unable to show the experimentally observed independence with respect to ms while matching the morphological features of the schlieren pictures

A new approach for the comprehensive study of a turbulent mixing zone induced by the Richtmyer-Meshkov instability

In this study we propose a new experimental and methodological approach dedicated to the analysis of the development of a turbulent mixing zone produced by the Richtmyer-Meshkov Instability. A brief description of the experimental device dedicated to the generation of the initial interface is first presented. An overview of the main results obtained by means of strioscopic, Particle Image Velocimetry (PIV) and tomoscopic time-resolved measurements are then provided. The spatio-temporal evolution of the macroscopic scale based on the thickness of the mixing zone is discussed on the basis of the time-resolved Schlieren data. A first step into a more comprehensive analysis of finer, local scales of the flow is introduced, based on the qualitative analysis of the velocity and density fields during the development of the mixing zone

Multi-modal image fusion for small animal studies in in-line PET /3T MRI

Congrès sous l’égide de la Société Française de Génie Biologique et Médical (SFGBM).National audienceIn the framework of small animal multi-modal imaging, the current progression of the IMAPPI project is illustrated by the design of an in-line PET/MRI prototype, coupled to a dedicated multi-resolution registration method allowing the robust fusion of data coming from both modalities. The first results show a good alignment of the data from tumor imaging at the level of the abdomen

Pyrosequencing for Mini-Barcoding of Fresh and Old Museum Specimens

DNA barcoding is an effective approach for species identification and for discovery of new and/or cryptic species. Sanger sequencing technology is the method of choice for obtaining standard 650 bp cytochrome c oxidase subunit I (COI) barcodes. However, DNA degradation/fragmentation makes it difficult to obtain a full-length barcode from old specimens. Mini-barcodes of 130 bp from the standard barcode region have been shown to be effective for accurate identification in many animal groups and may be readily obtained from museum samples. Here we demonstrate the application of an alternative sequencing technology, the four-enzymes single-specimen pyrosequencing, in rapid, cost-effective mini-barcode analysis. We were able to generate sequences of up to 100 bp from mini-barcode fragments of COI in 135 fresh and 50 old Lepidoptera specimens (ranging from 53–97 year-old). The sequences obtained using pyrosequencing were of high quality and we were able to robustly match all the tested pyro-sequenced samples to their respective Sanger-sequenced standard barcode sequences, where available. Simplicity of the protocol and instrumentation coupled with higher speed and lower cost per sequence than Sanger sequencing makes this approach potentially useful in efforts to link standard barcode sequences from unidentified specimens to known museum specimens with only short DNA fragments

Association Study of Common Genetic Variants and HIV- 1 Acquisition in 6,300 Infected Cases and 7,200 Controls

Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is known to tag the HLA-B*57:01 and B*27:05 alleles, as genome-wide significant (p = 3.6×10−11). However, restricting analysis to individuals with a known date of seroconversion suggested that this association was due to the frailty bias in studies of lethal diseases. Further analyses including testing recessive genetic models, testing for bulk effects of non-genome-wide significant variants, stratifying by sexual or parenteral transmission risk and testing previously reported associations showed no evidence for genetic influence on HIV-1 acquisition (with the exception ofCCR5Δ32 homozygosity). Thus, these data suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size

THE HOT-JUPITER KEPLER-17b: DISCOVERY, OBLIQUITY FROM STROBOSCOPIC STARSPOTS, AND ATMOSPHERIC CHARACTERIZATION

This paper reports the discovery and characterization of the transiting hot giant exoplanet Kepler-17b. The planet has an orbital period of 1.486 days, and radial velocity measurements from the Hobby–Eberly Telescope show a Doppler signal of 419.5+13.3−15.6 m s−1. From a transit-based estimate of the host star's mean density, combined with an estimate of the stellar effective temperature Teff = 5630 ± 100 from high-resolution spectra, we infer a stellar host mass of 1.06 ± 0.07 M☉ and a stellar radius of 1.02 ± 0.03 R☉. We estimate the planet mass and radius to be MP = 2.45 ± 0.11 MJ and RP = 1.31 ± 0.02 RJ. The host star is active, with dark spots that are frequently occulted by the planet. The continuous monitoring of the star reveals a stellar rotation period of 11.89 days, eight times the planet's orbital period; this period ratio produces stroboscopic effects on the occulted starspots. The temporal pattern of these spot-crossing events shows that the planet's orbit is prograde and the star's obliquity is smaller than 15°. We detected planetary occultations of Kepler-17b with both the Kepler and Spitzer Space Telescopes. We use these observations to constrain the eccentricity, e, and find that it is consistent with a circular orbit (e < 0.011). The brightness temperatures of the planet's infrared bandpasses are T3.6 μm = 1880  ±  100 K and T4.5 μm = 1770 ± 150 K. We measure the optical geometric albedo Ag in the Kepler bandpass and find Ag = 0.10 ± 0.02. The observations are best described by atmospheric models for which most of the incident energy is re-radiated away from the day side